Allegro™ STR Single-use Stirred Tank Bioreactors product photo Primary L

Allegro™ STR Single-use Stirred Tank Bioreactors

The Allegro STR bioreactor family combines Pall’s bioprocess engineering expertise, cell culture know-how and our drive for quality into a series of single-use bioreactors that deliver consistent and scalable cell culture performance across the range. The Allegro STR bioreactor family has a direct bottom-driven impellor allowing power inputs up to 0.25 W/kg, resulting in high oxygen transfer rates and short mixing times.

From the outset of the design, our technology placed strong emphasis toward providing a compact, ergonomic and intuitive turn key bioreactor design concept to maximize usability and process assurance, while maintaining optimal performance needed in a cell culture environment through several easy and intuitive operation features:

  • The single bottom-mounted impeller design allows the biocontainer to be packed into a compact unit that can be placed directly into the hardware with minimal operator manipulation
  • Installation and inflation of the biocontainer is achieved in < 30 minutes through a guided sequence via the Human Machine Interface (HMI)
  • The low aspect ratio of the systems minimize the operations that have to be performed at height
  • Automatic biocontainer deflation speeds up turnaround time, minimizes operator activity and reduces the overall volume of waste for disposal

All product contact surfaces in the Allegro STR bioreactors are single-use components and therefore the demands on maintenance, cleaning and cleaning validation are minimal. This makes single-use bioreactors the first choice for process development, CMO plants or multiproduct manufacturing facilities where maximum flexibility is required.

Extensive experiments were performed to characterize the bioreactor and gather data on mixing, mass transfer and cell culture performance. Additionally, all components of this bioreactor were rigorously tested, and several long term experiments were completed in order to ensure the integrity and compatibility of the materials with regards to cell culture demands. During the product development, 45 day life tests were performed under maximum operating conditions to prove the design of the single-use system: no leaks were observed during this testing. A smaller number of life tests were also performed for >100 days continuous operation with no leaks observed.

Allegro STR 50 bioreactor

Allegro STR 500 bioreactor



Left to right: Allegro 50, 200, 500, 1000, 2000 L bioreactors

Learn about our System and Instrumentation Services for Allegro™ STR Single-use Stirred Tank Bioreactors.

Learn about our Systems Service Contracts for Allegro™ STR Single-use Stirred Tank Bioreactors.

Our factory certified service engineers are experts in Pall equipment and are trained on the latest instrument and systems technology, product improvements, software and accessories.

Our field service engineers are located worldwide to ensure fast, efficient service response and provide constant coverage.

Learn more about our Worldwide Support.



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Description

The Allegro STR bioreactor family combines Pall’s bioprocess engineering expertise, cell culture know-how and our drive for quality into a series of single-use bioreactors that deliver consistent and scalable cell culture performance across the range. The Allegro STR bioreactor family has a direct bottom-driven impellor allowing power inputs up to 0.25 W/kg, resulting in high oxygen transfer rates and short mixing times.

From the outset of the design, our technology placed strong emphasis toward providing a compact, ergonomic and intuitive turn key bioreactor design concept to maximize usability and process assurance, while maintaining optimal performance needed in a cell culture environment through several easy and intuitive operation features:

  • The single bottom-mounted impeller design allows the biocontainer to be packed into a compact unit that can be placed directly into the hardware with minimal operator manipulation
  • Installation and inflation of the biocontainer is achieved in < 30 minutes through a guided sequence via the Human Machine Interface (HMI)
  • The low aspect ratio of the systems minimize the operations that have to be performed at height
  • Automatic biocontainer deflation speeds up turnaround time, minimizes operator activity and reduces the overall volume of waste for disposal

All product contact surfaces in the Allegro STR bioreactors are single-use components and therefore the demands on maintenance, cleaning and cleaning validation are minimal. This makes single-use bioreactors the first choice for process development, CMO plants or multiproduct manufacturing facilities where maximum flexibility is required.

Extensive experiments were performed to characterize the bioreactor and gather data on mixing, mass transfer and cell culture performance. Additionally, all components of this bioreactor were rigorously tested, and several long term experiments were completed in order to ensure the integrity and compatibility of the materials with regards to cell culture demands. During the product development, 45 day life tests were performed under maximum operating conditions to prove the design of the single-use system: no leaks were observed during this testing. A smaller number of life tests were also performed for >100 days continuous operation with no leaks observed.

Allegro STR 50 bioreactor

Allegro STR 500 bioreactor



Left to right: Allegro 50, 200, 500, 1000, 2000 L bioreactors

Learn about our System and Instrumentation Services for Allegro™ STR Single-use Stirred Tank Bioreactors.

Learn about our Systems Service Contracts for Allegro™ STR Single-use Stirred Tank Bioreactors.

Our factory certified service engineers are experts in Pall equipment and are trained on the latest instrument and systems technology, product improvements, software and accessories.

Our field service engineers are located worldwide to ensure fast, efficient service response and provide constant coverage.

Learn more about our Worldwide Support.

Applications

Typical applications include:

  • Suspension cell culture, using e.g. HEK293 cells, to produce viral vectors for gene therapy or vaccines
  • Insect cell culture, using e.g. Sf9 cells, to produce baculovirus for gene therapy
  • Suspension cell culture, using e.g. CHO cells, to produce monoclonal antibodies
  • Adherent cell culture, using e.g. VERO on microcarriers, to produce viral vectors for gene therapy or vaccines
  • Comparable rAAV9 titer achieved in scale up for gene therapy application

Type

Bioreactors

Use

Cell Culture

Ordering Information

Part Description Order Quantity
STR50-110NW Allegro STR 50, 110 V 1
STR50-230W Allegro STR 50, 230 V 1
STR50-110NW-R-SU Allegro STR 50, 110 V, Redundant SU Sensors 1
STR50-230W-R-SU Allegro STR 50, 230 V, Redundant SU sensors 1
STR200-110NW Allegro STR 200, 110 V 1
STR200-230W Allegro STR 200, 230 V 1
STR500-110NW Allegro STR 500, 110 V 1
STR500-230W Allegro STR 500, 230 V 1
STR1000-110NW Allegro STR 1000, 110 V 1
STR1000-230W Allegro STR 1000, 230 V 1
STR2000-110NW Allegro STR 2000, 110 V 1
STR2000-230W Allegro STR 2000, 230 V 1

Detailed ordering information is described in the product brochure.

Product Summary

A novel single-use bioreactor system that allows users to focus on optimizing the application rather than on the mechanics of bioreactor installation and operation

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